Heparin Low Doses and Standard doses Effect on Transradial Catheterization

Authors

  • Gul Shan Ahmad Punjab Institute of Cardiology, Lahore-Pakistan.
  • Tariq Ashraf Karachi Institute of Heart Diseases, Karachi-Pakistan.
  • Muhammad Zafarullah Punjab Institute of Cardiology, Lahore-Pakistan.
  • Safoora Anjum University of Lahore, Medical and Dental College, Lahore-Pakistan.
  • Samar Arfeen Punjab Institute of Cardiology, Lahore-Pakistan.

Keywords:

Heparin, Transradial, Catheterization, Doses, Radial Artery Occlusion

Abstract

Background: Transradial artery is being utilized by an expanding number of interventional cardiologists to perform percutaneous interventions. Nevertheless, occlusion of radial artery (RAO) is prominent after transradial (TR) catheterization. The use of anticoagulant drugs is one way to prevent RAO. The use of high-dose heparin and standard-dose heparin is still debatable. The present study will analyze the non-randomized controlled trials of standard and high doses of heparin for the prevention of radial artery occlusion after transradial catheterization.

Methodology: A prospective double-blinded non-randomized controlled trial was carried out. Demographic data on socio-economic statuses, such as age, occupation, gender, and smoking habits, were collected. Grouping was done so that patients may either be placed in group 1, which will receive 2500UI or into group 2, which will get 5000UI of unfractionated heparin. RAO was the critical endpoint of our study. Major bleeding, hematomas, and radial artery spasms were secondary outcome measures.

Results: 471 patients were made part of this study. 235 patients were placed in group A which received 2500IU, and 236 were placed in group B, which received 5000IU. RAO was noted to be significantly higher in the group that received the standard dose of UFH as compared to the group that received a high dose of UFH (8 % vs. 3.3 %, p = 0.005). Female gender (OR: 2.951, 95% CI: 1.57-5.46, p = 0.002), hypertension (OR: 0.02, 95% CI: p = 0.005 and standard dose UFH (OR: 2.822, 95% CI: 1.343 – 5.911, p =. 0.007) were found to be the independent predictors of RAO.

Conclusion: Weight-adjusted higher dosage of UFH in TRA for diagnosis yielded remarkable results in reducing the rates of early RAO against the standard administered dosage.

References

Turin TC, Shahana N, Wangchuk LZ, Specogna AV, Al Mamun M, Khan MA, et al. Burden of cardio-and cerebrovascular diseases and the conventional risk factors in South Asian population. Global heart. 2013;8(2):121-30.

Filion KB, Luepker RV. Cigarette smoking and cardiovascular disease: lessons from Framingham. Global heart. 2013;8(1):35-41.

Organization WH. Global status report on noncommunicable diseases 2014: World Health Organization; 2014.

Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, et al. Cardiovascular risk and events in 17 low-, middle-, and high-income countries. New England Journal of Medicine. 2014;371(9):818-27.

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Published

01-06-2022

How to Cite

Ahmad, G. S. ., Ashraf, T., Zafarullah, M. ., Anjum, S. ., & Arfeen, S. . (2022). Heparin Low Doses and Standard doses Effect on Transradial Catheterization. Pakistan Journal of Cardiovascular Interventions, 2(1), 11–19. Retrieved from https://www.pjcvi.com/index.php/home/article/view/32